124450-90-4Relevant academic research and scientific papers
Potassium fluoride on alumina - An efficient reagent for isomerization of N-[2-(Alkyl/Arylsulfonyl)ethyl]-2-methyl-5-nitro-1H-imidazoles
Bhujanga Rao,Gundu Rao,Singh
, p. 443 - 448 (1991)
KF/Al2O3 has been found to be an efficient reagent for a neat isomerization of 1-[2-(Alkyl/Arylsulphonyl)ethyl]-2-methyl-5-nitro-1H-imidazoles to the corresponding 4-nitro-isomers in more than 90% yields.
Isomerization of Tinidazole involving a Novel N-Alkyl Group Migration
Rao, A. K. S. Bhujanga,Prasad, Ramanujam S.,Rao, C. Gundu,Singh, Bajrang B.
, p. 1352 - 1353 (2007/10/02)
Tinidazole undergoes base-catalysed N-alkyl group migration in almost quantitative yields to give its 4-nitro isomer, an observation which may lead to a better understanding of the metabolism of this drug.
