1244558-01-7Relevant academic research and scientific papers
Discovery of novel α7 nicotinic receptor antagonists
Peng, Youyi,Zhang, Qiang,Snyder, Gretchen L.,Zhu, Hongwen,Yao, Wei,Tomesch, John,Papke, Roger L.,O'Callaghan, James P.,Welsh, William J.,Wennogle, Lawrence P.
experimental part, p. 4825 - 4830 (2010/09/18)
Two distinct families of small molecules were discovered as novel α7 nicotinic acetylcholine receptor (nAChR) antagonists by pharmacophore-based virtual screening. These novel antagonists exhibited selectivity for the neuronal α7 subtype over other nAChRs and good brain penetration. Neuroprotection was demonstrated by representative compounds 7i and 8 in a mouse seizure-like behavior model induced by the nerve agent diisopropylfluorophosphate (DFP). These novel nAChR antagonists have potential use as antidote for organophosphorus nerve agent intoxication.
