1244558-03-9Relevant academic research and scientific papers
Discovery of novel α7 nicotinic receptor antagonists
Peng, Youyi,Zhang, Qiang,Snyder, Gretchen L.,Zhu, Hongwen,Yao, Wei,Tomesch, John,Papke, Roger L.,O'Callaghan, James P.,Welsh, William J.,Wennogle, Lawrence P.
, p. 4825 - 4830 (2010)
Two distinct families of small molecules were discovered as novel α7 nicotinic acetylcholine receptor (nAChR) antagonists by pharmacophore-based virtual screening. These novel antagonists exhibited selectivity for the neuronal α7 subtype over other nAChRs and good brain penetration. Neuroprotection was demonstrated by representative compounds 7i and 8 in a mouse seizure-like behavior model induced by the nerve agent diisopropylfluorophosphate (DFP). These novel nAChR antagonists have potential use as antidote for organophosphorus nerve agent intoxication.
