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2,6-difluoro-N-{3-[2-(1-methylethyl)-5-(2-{[6-(4-morpholinyl)-3-pyridinyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1244641-64-2

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1244641-64-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1244641-64-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,4,6,4 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1244641-64:
(9*1)+(8*2)+(7*4)+(6*4)+(5*6)+(4*4)+(3*1)+(2*6)+(1*4)=142
142 % 10 = 2
So 1244641-64-2 is a valid CAS Registry Number.

1244641-64-2Downstream Products

1244641-64-2Relevant academic research and scientific papers

Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup

Stellwagen, John C.,Adjabeng, George M.,Arnone, Marc R.,Dickerson, Scott H.,Han, Chao,Hornberger, Keith R.,King, Alastair J.,Mook Jr., Robert A.,Petrov, Kimberly G.,Rheault, Tara R.,Rominger, Cynthia M.,Rossanese, Olivia W.,Smitheman, Kimberly N.,Waterson, Alex G.,Uehling, David E.

, p. 4436 - 4440 (2011/09/12)

A potent series of inhibitors against the B-RafV600E kinase have been developed that show excellent activity in cellular assays and good oral bioavailability in rats. The key structural features of the series are an arylsulfonamide headgroup, a thiazole core, and a fluorine ortho to the sulfonamide nitrogen. Crown Copyright

THIAZOLE SULFONAMIDE AND OXAZOLE SULFONAMIDE KINASE INHIBITORS

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Page/Page column 137-138, (2010/10/03)

The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents

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