1244643-80-8Relevant academic research and scientific papers
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup
Stellwagen, John C.,Adjabeng, George M.,Arnone, Marc R.,Dickerson, Scott H.,Han, Chao,Hornberger, Keith R.,King, Alastair J.,Mook Jr., Robert A.,Petrov, Kimberly G.,Rheault, Tara R.,Rominger, Cynthia M.,Rossanese, Olivia W.,Smitheman, Kimberly N.,Waterson, Alex G.,Uehling, David E.
, p. 4436 - 4440 (2011/09/12)
A potent series of inhibitors against the B-RafV600E kinase have been developed that show excellent activity in cellular assays and good oral bioavailability in rats. The key structural features of the series are an arylsulfonamide headgroup, a thiazole core, and a fluorine ortho to the sulfonamide nitrogen. Crown Copyright
THIAZOLE SULFONAMIDE AND OXAZOLE SULFONAMIDE KINASE INHIBITORS
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Page/Page column 171; 179, (2010/10/03)
The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents
