1244724-97-7 Usage
Uses
Used in Peptide Synthesis:
(R)-N-Fmoc-3-amino-4-(phenylthio)butanoic Acid is used as a building block for the synthesis of peptides, contributing to the formation of complex peptide structures. Its hydrophobic nature allows it to interact with hydrophobic regions in proteins and other biomolecules, enhancing the stability and functionality of the synthesized peptides.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (R)-N-Fmoc-3-amino-4-(phenylthio)butanoic Acid is utilized as a key component in the development of novel drug candidates. Its unique stereochemistry and hydrophobic properties enable the design of peptides with specific biological activities, targeting various therapeutic areas such as oncology, neurodegenerative diseases, and infectious diseases.
Used in Chemical Research:
(R)-N-Fmoc-3-amino-4-(phenylthio)butanoic Acid serves as a versatile tool in chemical research, particularly in the study of peptide synthesis, protein engineering, and the development of new synthetic methodologies. Its hydrophobicity and stereochemistry make it an attractive candidate for exploring the structure-activity relationships of peptides and understanding the underlying mechanisms of their interactions with biological targets.
Used in Biochemical Analysis:
In biochemical analysis, (R)-N-Fmoc-3-amino-4-(phenylthio)butanoic Acid can be employed as a reference compound or a standard for the development and validation of analytical methods, such as high-performance liquid chromatography (HPLC), mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy. Its distinct properties allow for accurate quantification and characterization of peptides and other biomolecules in complex biological samples.
Check Digit Verification of cas no
The CAS Registry Mumber 1244724-97-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,4,7,2 and 4 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1244724-97:
(9*1)+(8*2)+(7*4)+(6*4)+(5*7)+(4*2)+(3*4)+(2*9)+(1*7)=157
157 % 10 = 7
So 1244724-97-7 is a valid CAS Registry Number.
1244724-97-7Relevant academic research and scientific papers
Process for preparing sulfonamide compounds
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Paragraph 0415; 0453-0454; 0459-0460; 0494; 0579-0580; 0583, (2020/07/24)
The invention relates to a process for preparing sulfonamide compounds. The sulfonamide compound is an inhibitor of Bcl-2/Bcl-xL and is prepared from a compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorphenyl)-1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrole-3-yl
PROCESS FOR PREPARING SULFONAMIDE COMPOUNDS
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Page/Page column 69-71, (2020/09/03)
Provided are a process for preparing a sulfonamide compound which is an inhibitor of Bcl-2/Bcl-xL, including the compound (3R) -1- (3- (4- (4- (4- (3- (2- (4-chlorophenyl) -1-isopropyl-4-methylsulfonyl-5-methyl-1H-pyrrol-3-yl) -5-fluorophenyl) piperazine
METHOD FOR PREPARING SULFONAMIDES DRUGS
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Page/Page column 41; 45-46, (2020/07/21)
Provided is a method for preparing sulfonamides which are inhibitors of Bcl-2/ Bcl-xL, comprising the compound (3R)-1-(3-(4-(4-(4-(3-(2-(4-chlorophenyl) -1-isopropyl-4-methylsulfonyl-5-methyI-1H-pyrrol-3-yl)-5-fluorophenyl)piperazin-1-yI)-phenylam inosulf
Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2
Porter, Jason R.,Helmers, Mark R.,Wang, Ping,Furman, Jennifer L.,Joy, Stephen T.,Arora, Paramjit S.,Ghosh, Indraneel
supporting information; experimental part, p. 8020 - 8022 (2011/01/03)
We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.
