1244762-83-1Relevant academic research and scientific papers
STABILIZED NUCLEOTIDES FOR MEDICAL TREATMENT
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, (2016/02/12)
5′-Deuterated nucleosides and nucleotides and modifications thereof are provided for use in medical therapies, including as antiviral, anti-tumor and anti-neoplastic agents. In one embodiment, compounds, methods and uses are provided for the treatment of
DEUTERATED NUCLEOSIDE/TIDE DERIVATIVES
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Page/Page column 46-47, (2016/06/01)
The present invention provides nucleoside phosphoramidate compounds of Formula (I), where R1, R2a, R2b, R4, R5a, R5b, Rb5, Rb6 and D are as defined herein. The invention further includes pharmaceutical compositions comprising a compound of Formula (I), methods of use of these compounds for treating a viral infection, and methods of producing these compounds.
Synthesis and anti-HCV activity of 3′,4′-oxetane nucleosides
Chang, Wonsuk,Du, Jinfa,Rachakonda, Suguna,Ross, Bruce S.,Convers-Reignier, Serge,Yau, Wei T.,Pons, Jean-Francois,Murakami, Eisuke,Bao, Haiying,Steuer, Holly Micolochick,Furman, Phillip A.,Otto, Michael J.,Sofia, Michael J.
scheme or table, p. 4539 - 4543 (2010/11/03)
Hepatitis C virus afflicts approximately 180 million people worldwide and currently there are no direct acting antiviral agents available to treat this disease. Our first generation nucleoside HCV inhibitor, RG7128 has already established proof-of-concept
