1244763-18-5Relevant articles and documents
2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors
Cai, Jiaqiang,Bennett, D. Jonathan,Rankovic, Zoran,Dempster, Maureen,Fradera, Xavier,Gillespie, Jonathan,Cumming, Iain,Finlay, William,Baugh, Mark,Boucharens, Sylviane,Bruin, John,Cameron, Kenneth S.,Hamilton, William,Kerr, Jennifer,Kinghorn, Emma,McGarry, George,Robinson, John,Scullion, Paul,Uitdehaag, Joost C.M.,Van Zeeland, Mario,Potin, Dominique,Saniere, Laurent,Fouquet, Andre,Chevallier, Francois,Deronzier, Hortense,Dorleans, Cecile,Nicolai, Eric
scheme or table, p. 4447 - 4450 (2010/10/02)
Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl)pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin S inhibitors.