1244778-55-9Relevant academic research and scientific papers
The first catalytic asymmetric total synthesis of ent-hyperforin
Shimizu, Yohei,Shi, Shi-Liang,Usuda, Hiroyuki,Kanai, Motomu,Shibasaki, Masakatsu
scheme or table, p. 6569 - 6584 (2010/10/19)
The first catalytic asymmetric total synthesis of ent-hyperforin was described here in detail. Keys to the success were a catalytic asymmetric Diels-Alder reaction, a stereoselective Clasien rearrangement, an intramolecular aldol cyclization, and a vinylogous Pummerer rearrangement. Along with the successful synthetic route, several attempted approaches toward the construction of bicyclo[3.3.1] core and the C2 oxidation were discussed.
