1244783-75-2

Upstream product

• 765914-73-6 5-bromo-4-(2,4-difluorophenoxy)-2-methylaniline 

Downstream Products

• 765914-74-7 6-bromo-5-(2,4-difluorophenoxy)-1H-indazole 
• 956109-46-9 2,5-dioxopyrrolidin-1-yl-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylate 
• 956109-62-9 5-(2,4-difluorophenoxy)-1-(2-hydroxy-2-methylpropyl)-1H-indazole-6-carboxylic acid 
• 956109-64-1 5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole-6-carboxylic acid 
• 956109-61-8 1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)-2-methylpropan-2-ol 
• 956109-63-0 6-bromo-5-(2,4-difluorophenoxy)-1-(2-fluoro-2-methylpropyl)-1H-indazole 
• 1244783-77-4 1-(6-bromo-5-(2,4-difluorophenoxy)-1H-indazol-1-yl)propan-2-one 
• 914467-28-0 5-(2,4-difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 765914-76-9 5-(2,4-Difluorophenoxy)-1-isobutyl-1H-indazole-6-carbonitrile 
• 765914-40-7 5-(2,4-Difluorophenoxy)-1-isobutyl-1H-indazole-6-carboxylic acid 

Relevant academic research and scientific papers

P38 INHIBITORS AND METHODS OF USE THEREOF

Compounds of formula (I): in which A, B, X, Ar1, R8 and R4 have any of the meanings given in the specification, are inhibitors of p38 useful in the treatment and prevention of various disorders mediated by p38.

P38 inhibitors and methods of use thereof

Inhibitors of p38 and methods for producing these inhibitors are provided. Also provided are pharmaceutical compositions comprising the inhibitors of the invention, methods of utilizing the inhibitors and pharmaceutical compositions comprising said inhibi