1244784-59-5Relevant academic research and scientific papers
A highly efficient method for the N-alkylation of aminopyrazines: Synthesis of hydrophilic red fluorescent dyes
Poreddy, Amruta R.,Asmelash, Bethel,Neumann, William L.,Dorshow, Richard B.
, p. 2383 - 2392 (2010)
A robust and scalable method was developed for the synthesis of N,N-dialkylated aminopyrazines by a reductive amination route. These new fluorescent pyrazine analogues were shown to absorb and emit light at relatively long wavelengths (～50 nm) compared to the corresponding diaminopyrazines. The utility of these compounds was demonstrated by the synthesis of hydrophilic fluorescent probes with potential diagnostic applications. Georg Thieme Verlag Stuttgart · New York.
