124482-35-5Relevant academic research and scientific papers
Asymmetric Synthesis of 3-Substituted 2-exo-Methylenecyclohexanones via 1,5-Diastereoselection by Using a Chiral Amine
Tamura, Rui,Watabe, Ken-ichiro,Katayama, Hitoshi,Suzuki, Hitomi,Yamamoto, Yukio
, p. 408 - 410 (2007/10/02)
(S)-2-((2-(Methoxymethyl)-1-pyrrolidinyl)methyl)-2-cyclohexen-1-one (2) underwent asymmetric conjugate addition of R2CuLi in the presence of ZnBr2, followed by elimination of the chiral auxiliary pyrrolidine, to produce the optically active 3-substituted 2-exo-methylenecyclohexanones (3) in 90percent ee.
Me3SiCl PROMOTED CONJUGATE ADDITION OF ORGANOCUPRATES TO BASE-SENSITIVE CYCLIC α-(NITROALKYL)ENONES
Tamura, Rui,Tamai, Shinobu,Katayama, Hitoshi,Suzuki, Hitomi
, p. 3685 - 3688 (2007/10/02)
α-(Nitroalkyl)enones undergo mono β-conjugate addition of organocuprates in the presence of TMSCl to provide the corresponding silyl enol ethers in good to excellent yield, despite the presence of the acidic α-nitro protons.
