1244954-14-0 Usage
General Description
The chemical compound (1R,4S)-1,2,3,4-Tetrahydro-1,4-epoxynaphthalene-1-carboxylic Acid, also known as THNCA, is a synthetic intermediate in the production of the anticancer drug camptothecin. It is an epoxide derivative of naphthalene and is used in the synthesis of camptothecin analogs, which have shown potential in cancer treatment. THNCA undergoes various chemical conversions and modifications to ultimately produce camptothecin analogs with improved pharmaceutical properties. Its structure and reactivity make it a key component in the development of new cancer-fighting drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 1244954-14-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,4,9,5 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1244954-14:
(9*1)+(8*2)+(7*4)+(6*4)+(5*9)+(4*5)+(3*4)+(2*1)+(1*4)=160
160 % 10 = 0
So 1244954-14-0 is a valid CAS Registry Number.
1244954-14-0Relevant articles and documents
Tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid: A chiral derivatizing agent for the determination of the absolute configuration of secondary alcohols
Sungsuwan, Suttipun,Ruangsupapichart, Nopporn,Prabpai, Samran,Kongsaeree, Palangpon,Thongpanchang, Tienthong
supporting information; experimental part, p. 4965 - 4967 (2011/01/12)
A new chiral derivatizing agent, tetrahydro-1,4-epoxynaphthalene-1- carboxylic acid (THENA), with a represented syn-periplanar disposition of O-Ca-CαO as a part of the bicyclic system to lock the aromatic residue conformation and the availability of an in