1244978-16-2Relevant academic research and scientific papers
Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant
Kopka, Ihor E.,Lin, Linus S.,Jewell, James P.,Lanza, Thomas J.,Fong, Tung M.,Shen, Chun-Pyn,Lao, Zhege J.,Ha, Sookhee,Castonguay, Laurie G.,Van Der Ploeg, Lex,Goulet, Mark T.,Hagmann, William K.
scheme or table, p. 4757 - 4761 (2010/10/02)
The design, synthesis, and binding activity of ring constrained analogs of the acyclic cannabinoid-1 receptor (CB1R) inverse agonist taranabant 1 are described. The initial inspiration for these taranabant derivatives was its conformation 1a, determined b
