124499-67-8Relevant academic research and scientific papers
Construction of functionalized carbocycles having contiguous tertiary carbinol and all-carbon stereogenic centers
Reddy, Chennakesava,Babu, Srinivasarao Arulananda,Aslam, Nayyar Ahmad,Rajkumar, Vadla
, p. 2362 - 2380 (2013)
A highly stereoselective protocol is reported for customizing functionalized carbocyclic building blocks (β-hydroxy esters) and bicyclic lactones with a stereoarray that contains contiguous tertiary carbinol and all-carbon stereocenters. The efficient asymmetric induction and diastereofacial selective addition of allyl and propargyl indiums to hindered α,α-disubstituted cycloalkanones is presented. The stereochemistry of representative products was unequivocally established from single-crystal X-ray crystal structure analyses, and a plausible reaction pathway was proposed to support the high diastereofacial selectivity.
