1245022-95-0Relevant academic research and scientific papers
One-pot organocatalytic asymmetric synthesis of 3-nitro-1,2- dihydroquinolines by a dual-activation protocol
Wang, Yi-Feng,Zhang, Wei,Luo, Shu-Ping,Li, Bai-Lin,Xia, Ai-Bao,Zhong, Ai-Guo,Xu, Dan-Qian
, p. 1834 - 1838 (2009)
Generally, amine-catalyzed enantioselective transformations rely on chiral enamine or unsaturated iminium intermediates. Herein, we report a protocol involving dual activation by an aromatic iminium and hydrogenbonding. An enantioselective aza-Michael-Hen
Bifunctional thiourea-promoted cascade aza-Michael-Henry-dehydration reactions: Asymmetric preparation of 3-nitro-1,2-dihydroquinolines
Liu, Xiaoqian,Lu, Yixin
supporting information; experimental part, p. 4063 - 4065 (2010/10/02)
A cascade aza-Michael-Henry-dehydration reaction catalyzed by quinidine-derived tertiary amine-thiourea catalyst was developed via installation of suitable electron withdrawing groups at the amino function of aniline. This strategy led to a one-step preparation of chiral 3-nitro-1,2-dihydroquinolines in high yields and with up to 90% enantiomeric excesses.
