1245186-64-4Relevant academic research and scientific papers
Chiral Br?nsted acid-catalyzed regio- and enantioselective arylation of α,β-unsaturated trifluoromethyl ketones
Pei, Zeng-Kai,Zheng, Yan,Nie, Jing,Ma, Jun-An
scheme or table, p. 4658 - 4661 (2010/10/02)
The interesting examples of chiral phosphoric acid-catalyzed regio- and enantioselective arylation of α,β-unsaturated trifluoromethyl ketones were reported. The reaction proceeded well and the desired products were obtained in good yields (up to 99%) with moderate to good enantioselectivities (up to 88% ee). Several desired products were obtained with excellent optical purities after a single recrystallization. Subsequent reduction of enantiopure products with NaBH4 afforded two diastereomers of chiral trifluoromethyl-substituted secondary alcohols with high enantioselectivities (98% ee).
