124525-67-3Relevant academic research and scientific papers
Intramolecular dehydrative coupling of tertiary amines and ketones promoted by KO-t-Bu/DMF: A new synthesis of indole derivatives
Wei, Wen-Tao,Dong, Xue-Jiao,Nie, Shao-Zhen,Chen, Yan-Yan,Zhang, Xue-Jing,Yan, Ming
, p. 6018 - 6021 (2013)
A new synthesis of indole derivatives has been achieved through intramolecular dehydrative coupling of tertiary amines and ketones promoted by KO-t-Bu/DMF. The reaction probably proceeds via an α-amino alkyl radical pathway.
Diastereoselective synthesis of dihydro-quinolin-4-ones by a borane-catalyzed redox-neutral endo-1,7-hydride shift
Wicker, Garrit,Schoch, Roland,Paradies, Jan
supporting information, p. 3626 - 3630 (2021/05/10)
The borane-catalyzed synthesis of dihydroquinoline-4-ones is developed. The amino-substituted chalcones undergo a 1,7-hydride shift upon Lewis acid activation to form a zwitterionic iminium enolate, which collapses to the dihydroquinoline-4-one scaffold.
Bifunctional organic sponge photocatalyst for efficient cross-dehydrogenative coupling of tertiary amines to ketones
Zhang, Teng,Liang, Weiwei,Huang, Yuxing,Li, Xingrong,Liu, Yizhen,Yang, Bo,He, Chuanxin,Zhou, Xuechang,Zhang, Junmin
supporting information, p. 12536 - 12539 (2017/11/30)
A novel bifunctional organic sponge photocatalyst can enable the efficient coupling of tertiary amines with ketones in water. The asymmetric transformation can be also achieved by using this sponge photocatalyst.
Mild metal-free intramolecular oxidative alkylation of a Csp3-H bond adjacent to a nitrogen atom: A versatile approach to ring-fused tetrahydroquinolines
Zhang, Gen,Wang, Shoulei,Ma, Yunxia,Kong, Weidong,Wang, Rui
supporting information, p. 874 - 879 (2013/05/08)
A metal-free intramolecular oxidative cross-coupling reaction for the constructing Csp3-Csp3 bonds mediated by 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) under mild conditions was realized for the first time. This novel strategy prov
Unprecedented construction of C=C double bonds via Ir-catalyzed dehydrogenative and dehydrative cross-couplings
Nie, Shao-Zhen,Sun, Xiang,Wei, Wen-Tao,Zhang, Xue-Jing,Yan, Ming,Xiao, Jian-Liang
supporting information, p. 2394 - 2397 (2013/06/27)
Unprecedented constructions of C=C double bonds have been achieved by Ir-catalyzed intramolecular dehydrogenative and dehydrative cross-coupling of tertiary amines and ketones. The reactions are proposed to proceed via an Ir-mediated C-H activation mechan
The "tert-amino effect" in heterocyclic chemistry: synthesis of tetra- and pentacyclic compounds
Nijhuis, W. H. N.,Leus, G. R. B.,Egberink, R. J. M.,Verboom, W.,Reinhoudt, D. N.
, p. 172 - 178 (2007/10/02)
A new and covenient route for the synthesis of several heterotetra- and pentacyclic compounds is presented.Heating the 2-vinyl-N,N-dialkylanilines 3a-h, synthesized from the aldehydes 2a-f,h or the acetophenone 2g and malonitrile or ethyl cyanoacetate, in
