1245282-58-9Relevant academic research and scientific papers
COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES
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Page/Page column 173, (2016/06/14)
This invention provides novel compounds of formulae (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein the substituents are as defined in the specification. The present invention also relates to the novel compounds for use as a medicine, more in particular for the prevention or treatment of amyloid-related diseases, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such amyloid-related diseases. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.
Anti-HIV and antiplasmodial activity of original flavonoid derivatives
Casano, Gilles,Dumtre, Aurélien,Pannecouque, Christophe,Hutter, Sébastien,Azas, Nadine,Robin, Maxime
experimental part, p. 6012 - 6023 (2010/10/02)
In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum
