1245282-69-2

Upstream product

• 1245282-54-5 (E)-N-(4-hydroxy-3-(3-(2-methoxyphenyl)acryloyl)phenyl) acetamide 
• 1146897-25-7 C₁₈H₁₇NO₄ 
• 7298-67-1 5-acetamido-2-hydroxyacetophenone 
• 135-02-4 ortho-anisaldehyde 

Downstream Products

• 1245282-76-1 6-amino-3-hydroxy-2-(2-methoxyphenyl)-4H-chromen-4-one 
• 1245282-85-2 N-(3-methoxy-2-(2-methoxyphenyl)-4-oxo-4H-chromen-6-yl)acetamide 
• 1245282-94-3 6-amino-3-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one 

Relevant academic research and scientific papers

COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES

This invention provides novel compounds of formulae (I) or (II) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) (II) wherein the substituents are as defined in the specification. The present invention also relates to the novel compounds for use as a medicine, more in particular for the prevention or treatment of amyloid-related diseases, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, disorders characterized by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such amyloid-related diseases. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

Synthesis and complete assignment of the 1H and 13C NMR signals of new acetamido and aminoflavonoid derivatives

The complete 1H and13C NMR assignment of 9 acetamidochalcones, 18 acetamidoflavones, 18 aminoflavones, 9 acetamidoflavonols and 9 aminoflavonols has been performed using one- and two-dimensional NMR techniques including COSY, HMQC and HMBC experiments. Copyright

Anti-HIV and antiplasmodial activity of original flavonoid derivatives

In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum