1245285-36-2Relevant academic research and scientific papers
One-pot, pseudo-five-component synthesis of bis[2-(arylimino)-1,3- thiazolidin-4-ones]
Alizadeh, Abdolali,Noaparast, Zohreh,Sabahno, Hamideh,Zohreh, Nasrin
, p. 1401 - 1406 (2010)
Synthesis and characterization of bis[2-(arylimino)-1,3-thiazolidin-4-ones] are described. The onepot, pseudo-five-component reaction of an aliphatic diamine, isothiocyanatobenzene, and dialkyl but-2-ynedioate at room temperature in anhydrous CH2Cl2 gives the title compound in relatively high yield. Under the same conditions, aromatic 1,2-diamines yield 2-(arylimino)-N-(enaminoaryl)-1,3-thiazolidin-4-ones in a pseudo-four-component reaction. Their structures were corroborated spectroscopically (IR, 1H- and 13C-NMR, and EI-MS) and by elemental analyses. A plausible mechanism for this type of cyclization is proposed (Scheme 3).
