1245449-11-9

Basic information

• Product Name: 1-(2-(methylthio)-4-phenyl-4H-chromen-3-yl)ethanone
• CAS NO: 1245449-11-9
• Molecular Weight: 296.39
• Mol File: 1245449-11-9.mol

Chemical Properties

• CAS DataBase Reference: 1-(2-(methylthio)-4-phenyl-4H-chromen-3-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(methylthio)-4-phenyl-4H-chromen-3-yl)ethanone(1245449-11-9)
• EPA Substance Registry System: 1-(2-(methylthio)-4-phenyl-4H-chromen-3-yl)ethanone(1245449-11-9)

Safety Data

• Hazardous Substances Data: 1245449-11-9(Hazardous Substances Data)

Upstream product

• 17649-86-4 4,4-bis(methylthio)but-3-en-2-one 
• 40473-50-5 2-(hydroxy(phenyl)methyl)phenol 

Relevant articles and documents

One-pot synthesis of polyfunctionalized 4H-chromenes and dihydrocoumarins based on copper(II) bromide-catalyzed C-C coupling of benzylic alcohols with ketene dithioacetals

The synthesis of polyfunctionalized 4Hchromenes 3 and dihydrocoumarins 4 has been developed from the same substrates. Catalyzed by copper(II) bromide (0.3 equiv.), the reactions of the easily available ketene dithioacetals 1 with 2-(hydroxymethyl)phenols 2 lead to 4/7-chromenes 3 in high to excellent yields in dichloromethane solvent, whereas, 3,4-trans-disubstituted dihydrocoumarins 4 are obtained in high yields with high diastereoselectivities by prolonging the reaction time or changing the solvent from dichloromethane to acetonitrile.