1245459-11-3Relevant academic research and scientific papers
Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells
Zheng, Liang-Wen,Li, Ying,Ge, Di,Zhao, Bao-Xiang,Liu, Ying-Rui,Lv, Hong-Shui,Ding, Jun,Miao, Jun-Ying
, p. 4766 - 4770 (2010)
A series of novel oxime-containing pyrazole derivatives were synthesized by the reaction of ethyl 3-phenyl-1H-pyrazole-5-carboxylate derivatives and 2-bromo-1-phenylethanone followed by the reaction with hydroxylamine hydrochloride. The structures were determined by IR, 1H NMR, HRMS, and X-ray analysis. A dose- and time-dependent inhibition of proliferation was observed in A549 lung cancer cell after compound treatment. Inhibition of growth was mainly attributed to the autophagy induction.
