124549-82-2Relevant articles and documents
A general approach to the total synthesis of yuehchukene and its analogues. A novel anti-implantation agent
Kutney, James Peter,Lopez, Francisco Javier,Huang, Shyl-Pyng,Kurobe, Hiroshi
, p. 565 - 572 (2007/10/02)
A versatile synthetic strategy has been developed for the synthesis of the interesting dimeric indole natural product yuehchukene (17) and its epimer, 6a-epi-yuehchukene (22). Due to the anti-implantation activity associated with 17, it is important to develop a synthetic route not only to 17, but to a family of yuehchukene analogues with better chemical stability and/or elevated biological activity. The strategy described here and which utilizes the readily available and inexpensive isophorone (1) satisfies these requirements.