1245501-96-5Relevant academic research and scientific papers
Robust generation of lead compounds for protein-protein interactions by computational and MCR chemistry: P53/Hdm2 antagonists
Czarna, Anna,Beck, Barbara,Srivastava, Stuti,Popowicz, Grzegorz M.,Wolf, Siglinde,Huang, Yijun,Bista, Michal,Holak, Tad A.,Doemling, Alexander
supporting information; experimental part, p. 5352 - 5356 (2010/10/20)
The parallel discovery of multiple scaffolds useful to antagonize the cancer-relevant proteinprotein interaction p53/Hdm2 is described. The new method is based on the tightly interwoven interplay of multicomponent reaction chemistry, structural biology, c
