1245505-19-4Relevant articles and documents
Discovery of a novel class of triazolones as Checkpoint Kinase inhibitors - Hit to lead exploration
Oza, Vibha,Ashwell, Susan,Brassil, Patrick,Breed, Jason,Deng, Chun,Ezhuthachan, Jay,Haye, Heather,Horn, Candice,Janetka, James,Lyne, Paul,Newcombe, Nicholas,Otterbien, Ludo,Pass, Martin,Read, Jon,Roswell, Sian,Su, Mei,Toader, Dorin,Yu, Dingwei,Yu, Yan,Valentine, Anna,Webborn, Peter,White, Ann,Zabludoff, Sonya,Zheng, Xiaolan
scheme or table, p. 5133 - 5138 (2010/10/19)
Checkpoint Kinase-1 (Chk1, CHK1, CHEK1) is a Ser/Thr protein kinase that mediates cellular responses to DNA-damage. A novel class of Chk1 inhibitors, triazoloquinolones/triazolones (TZ's) was identified by high throughput screening. The optimization of th