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1245514-96-8

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1245514-96-8 Usage

General Description

6-bromospiro[3H-indene-2,4'-cyclohexane]-1,1'-dione is a chemical compound that belongs to the group of spiro compounds. It is a heterocyclic compound containing a spiro ring system, with a bromine atom attached to one of the carbon atoms. 6-bromospiro[3H-indene-2,4'-cyclohexane]-1,1'-dione has potential applications in medicinal chemistry, particularly in the development of new pharmaceuticals. Its unique structure and properties make it an interesting target for research and development in the field of drug discovery. However, further studies and investigations are needed to fully understand the potential uses and effects of this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 1245514-96-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,5,1 and 4 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1245514-96:
(9*1)+(8*2)+(7*4)+(6*5)+(5*5)+(4*1)+(3*4)+(2*9)+(1*6)=148
148 % 10 = 8
So 1245514-96-8 is a valid CAS Registry Number.

1245514-96-8Relevant articles and documents

COMBINATION OF A BACE INHIBITOR AND AN ANTIBODY OR ANTIGEN-BINDING FRAGMENT FOR THE TREATMENT OF A DISORDER ASSOCIATED WITH THE ACCUMULATION OF AMYLOID BETA

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Page/Page column 99, (2017/10/11)

The present disclosure provides for methods for treating a subject having a disease or disorder associated with the accumulation of amyloid beta, comprising administering to the subject a BACE inhibitor and an antibody or antigen-binding fragment that binds to amyloid beta n-42. In some embodiments, the disease or disorder is Alzheimer's Disease.

CYCLOALKYL ETHER COMPOUNDS AND THEIR USE AS BACE INHIBITORS

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Page/Page column 19, (2014/01/09)

Cycloalkyl ether compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Αβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss

MONO-FLUORO BETA-SECRETASE INHIBITORS

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Page/Page column 35; 36, (2013/04/25)

Beta-secretase inhibitors, of formula (I) as described in the specification, pharmaceutical compositions comprising them and therapeutic methods using them for the treatment and/or prevention of Αβ-related pathologies such as Down's syndrome, β-amyloid an

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