1245526-82-2 Usage
General Description
Glucocorticoid receptor agonists are a class of chemicals that bind to and activate the glucocorticoid receptor, a type of nuclear receptor that plays a key role in regulating the body's response to stress and inflammation. When activated, these receptors can modulate gene expression, leading to anti-inflammatory and immunosuppressive effects. This class of chemicals is commonly used in the treatment of inflammatory and autoimmune conditions, such as asthma, rheumatoid arthritis, and allergic reactions. By binding to the glucocorticoid receptor, agonists can help to reduce inflammation and the body's immune response, providing relief from symptoms associated with these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1245526-82-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,5,2 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1245526-82:
(9*1)+(8*2)+(7*4)+(6*5)+(5*5)+(4*2)+(3*6)+(2*8)+(1*2)=152
152 % 10 = 2
So 1245526-82-2 is a valid CAS Registry Number.
1245526-82-2Relevant articles and documents
Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics
Riether, Doris,Harcken, Christian,Razavi, Hossein,Kuzmich, Daniel,Gilmore, Thomas,Bentzien, J?rg,Pack, Edward J.,Souza, Donald,Nelson, Richard M.,Kukulka, Alison,Fadra, Tazmeen N.,Zuvela-Jelaska, Ljiljana,Pelletier, Josephine,Dinallo, Roger,Panzenbeck, Mark,Torcellini, Carol,Nabozny, Gerald H.,Thomson, David S.
experimental part, p. 6681 - 6698 (2010/12/19)
Syntheses and structure-activity relationships (SAR) of nonsteroidal glucocorticoid receptor (GR) agonists are described. These compounds contain azaindole moieties as A-ring mimetics and display various degrees of in vitro dissociation between gene trans