1245550-46-2Relevant academic research and scientific papers
One-pot synthesis of imidazole-4-carboxylates by microwave-assisted 1,5-electrocyclization of azavinyl azomethine ylides
Preti, Lisa,Attanasi, Orazio A.,Caselli, Emilia,Favi, Gianfranco,Ori, Claudia,Davoli, Paolo,Felluga, Fulvia,Prati, Fabio
experimental part, p. 4312 - 4320 (2010/10/21)
Diversely functionalized imidazole-4-carboxylates were synthesized by microwave-assisted 1,5-eletrocyclization of 1,2diaza-l,3-diene-derived azavinyl azomethine ylides. 1,2-Diaza-1,3-dienes were treated with primary aliphatic or aromatic amines and subjected to microwave irradiation in the presence of aldehydes. 3-Alkyl- and 3-arylimidazole-4-carboxylates were prepared in good yields through a one-pot multicomponent procedure. Modulation of the substituents at C-2, N-3, and C-5 was possible, and 2-unsubstituted imidazoles were obtained when paraformaldehyde was used.
