1245554-95-3Relevant academic research and scientific papers
Triflic acid promoted tandem ring-closure-aryl-migration of 2-amino chalcone epoxide: A new synthetic route to azaisoflavones
Praveen, Chandrasekaran,Parthasarathy, Kannabiran,Perumal, Paramasivan T.
, p. 1635 - 1640 (2010)
An unprecedented TfOH-promoted tandem ring-closure-aryl-migration of 2′-amino chalcone epoxide leading to 3-aryl-4(1H)-quinolones (azaisoflavones) was achieved. The outcome of the reaction was confirmed by NMR analysis and rationalized through the intermediacy of a phenonium ion. This synthetic protocol furnishes azaisoflavones straightforwardly from simple starting materials under mild conditions. Georg Thieme Verlag Stuttgart New York.
