1245605-03-1Relevant articles and documents
The mercaptomethyl group facilitates an efficient one-pot ligation at Xaa-Ser/Thr for (Glyco)peptide synthesis
Hojo, Hironobu,Ozawa, Chinatsu,Katayama, Hidekazu,Ueki, Akiharu,Nakahara, Yuko,Nakahara, Yoshiaki
, p. 5318 - 5321 (2010)
Going native: A mercaptomethyl group on the side-chain hydroxy group of serine and threonine residues facilitates a native chemical ligation reaction at the Xaa-Ser/Thr site (see scheme; R=H or Me). The intermediate thioester is treated to achieve an S- t