1245616-49-2

Upstream product

• 1245616-67-4 (1S,2S)-1-(3,3-dimethylcycloprop-1-enyl)-3-(4-methoxybenzyloxy)-2-methylpropan-1-ol 
• 4392-24-9 3-bromo-1-phenyl-1-propenyl bromide 

Downstream Products

• 1245616-59-4 (1S,4S,6R,7R)-5-isopropylidene-4-[(S)-2-(4-methoxybenzyloxy)-1-methylethyl]-7-phenyl-3-oxabicyclo[4.1.0]heptane 

Relevant academic research and scientific papers

Synthesis of 3-oxa- and 3-azabicyclo[4.1.0]heptanes by gold-catalyzed cycloisomerization of cyclopropenes

Equation Presented Allyl 3,3-dimethylcyclopropenylcarbinyl ethers or sulfonamides undergo gold-catalyzed cycloisomerization leading to 5-isopropylidene-3-oxa- and 3-azabicyclo[4.1.0]heptanes in excellent yields and with high diastereoselectivities. These reactions constitute the first examples of intramolecular cyclopropanation of an alkene by a gold carbene generated by electrophilic ring opening of a cyclopropene in the presence of gold(I) chloride.