1245618-51-2Relevant academic research and scientific papers
Bromotriphenylphosphonium salt promoted tandem one-pot cyclization to optically active 2-Aryl-1,3-oxazolines
Jiang, Haizhen,Yuan, Shijie,Wan, Wen,Yang, Kun,Deng, Hongmei,Hao, Jian
experimental part, p. 4227 - 4236 (2010/10/04)
Optically active 2-aryl-1,3-oxazolines, such as aromatic carbocycles, heterocycle-binding 4-benzyl (or phenyl)-1,3oxazolines and their 5-benzyl (or phenyl)-l,3-oxazoline isomers were successfully prepared through a bromotriphenylphosphonium salt promoted aziridine ring formation and ring opening sequential process involving tandem one pot cyclization of chiral 2-amino-3-phenylpropanol or 2amino-2-phenylethanol with various aromatic acids in toluene at 90 °C in moderate to excellent yields. The mechanism of this tandem process was also substantiated experimentally.
