124562-08-9Relevant academic research and scientific papers
Synthesis, Conformation, and Immunosuppressive Activities of Three Analogues of Cyclosporin A Modified in the 1-Position
Aebi, Johannes D.,Deyo, Donald T.,Sun, Chong Qing,Guillaume, Dominique,Dunlap, Brian,Rich, Daniel H.
, p. 999 - 1009 (2007/10/02)
The syntheses of three new cyclosporin A (CsA) analogues that contain novel MeBmt derivatives in the 1-position are described.The MeBmt analogue that contains an additional methyl group on C4, (2S,3R,6E)-4,4-dimethyl-3-hydroxy-2-(N-methylamino)-6-octenoic
ASYMMETRIC SYNTHESIS OF THREO β-HYDROXY-α1-N-METHYL AMINO ACIDS AND MeBMT ANALOGS VIA EPOXIDES. (PART 1)
Sun, Chong-Qing,Rich, Daniel H.
, p. 5205 - 5208 (2007/10/02)
Threo 2-oxazolidinones 5, readily available by regiospecific intramolecular opening of cis-epoxyurethanes 4, were utilized for the synthesis of β-hydroxy-α-N-methyl amino acids.New analogs of the cyclosporine amino acid, MeBmt, are made possible by this route.
