1245633-05-9

Basic information

• Product Name: diethyl (R)-1-(2-(2'-fluorophenyl)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate
• CAS NO: 1245633-05-9
• Molecular Weight: 326.325
• Mol File: 1245633-05-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl (R)-1-(2-(2'-fluorophenyl)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (R)-1-(2-(2'-fluorophenyl)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate(1245633-05-9)
• EPA Substance Registry System: diethyl (R)-1-(2-(2'-fluorophenyl)-1-oxopropan-2-yl)hydrazine-1,2-dicarboxylate(1245633-05-9)

Safety Data

• Hazardous Substances Data: 1245633-05-9(Hazardous Substances Data)

Upstream product

• 914080-20-9 2-(2'-fluorophenyl)propanal 
• 1972-28-7 diethylazodicarboxylate 

Relevant articles and documents

Asymmetric synthesis of deuterated and fluorinated aromatic α,α-disubstituted amino acid derivatives

We herein present organocatalytic approaches to synthesize fluorinated and deuterated α-substituted phenylglycine derivatives. Whereas the addition of diethyl azodicarboxylate to fluorinated α-substituted aldehydes furnishes chiral non-racemic compounds, the use of chloramine-T as a nitrogen source represents a rapid access to sulfamidated fluorinated amino acid precursors. Additionally, further functionalization was achieved through the palladium-catalyzed coupling of a p-bromosubstituted aldehyde with a range of fluorine or deuterium-containing boronic acids. Oxidation of the aldehyde function and cleavage of the protection group of the nitrogen give way to the free fluorinated unnatural amino acids.