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Methyl 5-chloro-1H-indole-6-carboxylate is a synthetic chemical compound characterized by its indole core structure, an aromatic heterocyclic organic compound, and unique functional groups, including a methyl ester and a chlorine atom. The indole ring endows the molecule with specific properties that can be beneficial in various applications, such as in drug development or as a precursor in synthetic chemistry. The chlorine atom attached enhances its reactivity, potentially allowing for further chemical modifications. As with any synthetic chemical, handling should be done with standard safety precautions due to possible hazards or negative health impacts.

1245643-61-1

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1245643-61-1 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 5-chloro-1H-indole-6-carboxylate is used as a pharmaceutical intermediate for its potential role in drug development. The indole ring and chlorine atom in its structure can be exploited to create new compounds with therapeutic properties, contributing to the discovery of novel medications.
Used in Synthetic Chemistry:
Methyl 5-chloro-1H-indole-6-carboxylate is used as a chemical precursor in synthetic chemistry. Its reactivity, due to the chlorine atom, makes it a valuable building block for the synthesis of more complex molecules, which can be used in various chemical and industrial processes.
Used in Research and Development:
Methyl 5-chloro-1H-indole-6-carboxylate is used as a research compound in academic and industrial laboratories. Its unique structure and properties make it an interesting subject for studies aimed at understanding its chemical behavior and potential applications in various fields, such as materials science or biotechnology.

Check Digit Verification of cas no

The CAS Registry Mumber 1245643-61-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,6,4 and 3 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1245643-61:
(9*1)+(8*2)+(7*4)+(6*5)+(5*6)+(4*4)+(3*3)+(2*6)+(1*1)=151
151 % 10 = 1
So 1245643-61-1 is a valid CAS Registry Number.

1245643-61-1Relevant academic research and scientific papers

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists

McCoull, William,Barton, Peter,Brown, Alastair J. H.,Bowker, Suzanne S.,Cameron, Jennifer,Clarke, David S.,Davies, Robert D. M.,Dossetter, Alexander G.,Ertan, Anne,Fenwick, Mark,Green, Clive,Holmes, Jane L.,Martin, Nathaniel,Masters, David,Moore, Jane E.,Newcombe, Nicholas J.,Newton, Claire,Pointon, Helen,Robb, Graeme R.,Sheldon, Christopher,Stokes, Stephen,Morgan, David

, p. 6128 - 6140 (2014/08/18)

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identified an acylurea series of ghrelin modulators from high throughput screening and optimized binding affinity through structure-activity relationship studies. Furthermore, we identified specific substructural changes, which switched partial agonist activity to inverse agonist activity, and optimized physicochemical and DMPK properties to afford the non-CNS penetrant inverse agonist 22 (AZ-GHS-22) and the CNS penetrant inverse agonist 38 (AZ-GHS-38). Free feeding efficacy experiments showed that CNS exposure was necessary to obtain reduced food intake in mice, and it was demonstrated using GHS-R1a null and wild-type mice that this effect operates through a mechanism involving GHS-R1a.

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