1245644-68-1

Basic information

• Product Name: 8-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine
• Synonyms: 8-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine
• CAS NO: 1245644-68-1
• Molecular Formula: C6H5ClN4
• Molecular Weight: 169
• Mol File: 1245644-68-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 8-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine(1245644-68-1)
• EPA Substance Registry System: 8-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine(1245644-68-1)

Safety Data

• Hazardous Substances Data: 1245644-68-1(Hazardous Substances Data)

Upstream product

• 2402-77-9 2,3-dichloro-pyridine 
• 39620-04-7 2-amino-3-chloropyridine 

Relevant articles and documents

TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE

The present invention relates to triazolo pyridines of formula (II) and their use as modulators of ?-secretase. In particular, the present invention relates to compounds which interfere with ?-secretase and/or its substrate and therefore modulate the form

Oxidative cyclization of 1-(pyridin-2-yl)guanidine derivatives: A synthesis of [1,2,4]triazolo[1,5-a]pyridin-2-amines and an unexpected synthesis of [1,2,4]triazolo[4,3-a]pyridin-3-amines

Oxidative cyclization of 1-(pyridin-2-yl)guanidine derivatives using N-chlorosuccinimide and aqueous potassium carbonate has been investigated. Chlorination of 1-(5-nitropyridin-2-yl)guanidine by N-chlorosuccinimide in methanol followed by addition of aqueous potassium carbonate gave rise to cyclization and afforded 6-nitro-[1,2,4]triazolo[1,5-a]pyridin-2-amine in one-pot. In the course of studying the scope and limitation of the reaction, it was found that some of the examined 1-(pyridin-2-yl)guanidine derivatives gave not only the desired [1,2,4]triazolo[1,5-a]pyridin-2-amines but also unexpected [1,2,4]triazolo[4,3-a]pyridin-3-amine products. As plausible reaction mechanisms of this oxidative cyclization, diazirine formation and nitrene formation are presented.