1245646-10-9

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Tert-butyl 4-hydroxy-2-oxopiperidine-1-carboxylate is used as a reagent in organic synthesis for the production of pharmaceuticals and agrochemicals. Its role in these industries is crucial due to its ability to contribute to the synthesis of various active ingredients and compounds that have medicinal or agricultural applications.
Used in Food Additive Manufacturing:
In the food industry, tert-butyl 4-hydroxy-2-oxopiperidine-1-carboxylate is used as a component in the manufacturing of food additives. Its inclusion in this sector is due to its potential to enhance the characteristics of food products, such as flavor, texture, or shelf life.
Used in Fragrance Production:
tert-butyl 4-hydroxy-2-oxopiperidine-1-carboxylate also finds application in the fragrance industry, where it is used in the production of various scents. Its use in this context is attributed to its ability to contribute to the creation of complex and unique olfactory profiles.
Used in Dye Manufacturing:
Furthermore, tert-butyl 4-hydroxy-2-oxopiperidine-1-carboxylate is utilized in the manufacturing of dyes, where it plays a role in developing a range of colorants for different applications, including textiles, plastics, and other materials. Its contribution to this field lies in its capacity to form stable and vibrant color compounds.

Upstream product

• 845267-78-9 tert-butyl 2,4-dioxopiperidine-1-carboxylate 
• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 
• 85908-96-9 2-oxopiperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 845267-78-9 tert-butyl 2,4-dioxopiperidine-1-carboxylate 
• 128372-89-4 6-oxo-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Regio- and stereoselective hydroxylation of N-substituted piperidin-2-ones with Sphingomonas sp. HXN-200

High activity, excellent regioselectivity, and opposite enantioselectivity were achieved in the hydroxylation of N-benzyl- and N-tert-butoxycarbonylpiperidin-2-one with Sphingomonas sp. HXN-200. High yield preparations of 4-hydroxypiperidin-2-ones were demonstrated in a bioreactor and in a shaking flask by use of the frozen/thawed cells as biocatalyst. The absolute configuration for the bioproducts was established.

CCR2 MODULATORS

Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (I) and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of CCR2 receptors.

Regio- and stereoselective biohydroxylations with a recombinant escherichia coli expressing P450pyr monooxygenase of sphingomonas Sp. HXN-200

A recombinant Escherichia coli expressing P450pyr monooxygenase of Sphingomonas sp. HXN-200 was developed as a useful biocatalyst for regio- and stereoselective hydroxylations, with no side reaction and easy cell growth. The resting E. coli cells showed an activity of 4.1 U/g cdw and 9.9 U/g cdw for the hydroxylation of N-benzylpyrrolidin-2-one 1 and N-benzyloxycarbonylpyrrolidine 3, respectively, being as active as the wide-type strain. Biohydroxylation of N-benzylpyrrolidin-2-one 1 with the resting cells gave (S)-N-benzyl-4- hydroxypyrrolidin-2-one 2 in >99% ee and 10.8 mM, a 2.6 times increase of product concentration in comparison with the wild-type strain. Biohydroxylation of N-tert-butoxycarbonylpiperidin-2-one 5, N-benzylpiperidine 7 and N-tert-butoxycarbonylazetidine 9 with the E. coli cells afforded the corresponding 4-hydroxypiperidin-2-one 6, 4-hydroxypiperidine 8, and 3-hydroxyazetidine 10 in 14 mM, 17 mM, and 21 mM, respectively. Moreover, hydroxylation of (-)-β-pinene 11 with the recombinant E. coli cells showed excellent regio- and stereoselectivity and gave (1R)-trans-pinocarveol 12 in 82% yield and 4.1 mM, which is over 200 times higher than that obtained with the best biocatalytic system known thus far. The recombinant strain was also able to hydroxylate other types of substrates with unique selectivity: biohydroxylation of norbornane 13 gave exo-norbornaeol 14, with exo/endo selectivity of 95%; tetralin 15 and 6-methoxytetralin 17 were hydroxylated at the non-activated 2-position, for the first time, with regioselectivities of 83-84%. Copyright