1245648-17-2

Basic information

• Product Name: (R)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate
• Synonyms: (R)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate
• CAS NO: 1245648-17-2
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.26276
• Mol File: 1245648-17-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate(1245648-17-2)
• EPA Substance Registry System: (R)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate(1245648-17-2)

Safety Data

• Hazardous Substances Data: 1245648-17-2(Hazardous Substances Data)

Usage

General Description

(R)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate is a compound with the chemical formula C11H21NO3. It is a carbamate derivative with a tetrahydro-2H-pyran-3-ylcarbamate group attached to a (R)-tert-butyl moiety. (R)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate is commonly used in organic synthesis as a chiral building block and precursor for the preparation of various pharmaceuticals, agrochemicals, and natural products. It has potential applications in the development of new drugs and biologically active compounds due to its unique structural properties. Additionally, it has been studied for its potential use as a chiral ligand in asymmetric catalysis. Overall, (R)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate is a valuable chemical compound with diverse applications in the field of organic chemistry and drug discovery.

Upstream product

• 162955-48-8 [(1S)-4-hydroxy-1-(hydroxymethyl)butyl]carbamic acid tert-butyl ester 
• 59279-60-6 dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 56-86-0 L-glutamic acid 
• 870-46-2 t-butoxycarbonylhydrazine 
• 110-87-2 3,4-dihydro-2H-pyran 
• 1015476-53-5 1-tert-butoxycarbonylamino-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 

Relevant articles and documents

Kilogram synthesis of (S)-3-aminopyran from l -glutamic acid

We describe the development of a concise route to prepare kilogram quantities of (S)-3-aminopyran, a key intermediate in the synthesis of a Jak1 inhibitor. The chiral amine was introduced via a chiral-pool approach and involves using inexpensive, commerci

Radical-transfer hydroamination of olefins with N-aminated dihydropyridines

An efficient synthesis of N-phthalimidyl, benzamidyl, acetamidyl, carbamoyl, and ureayl derivatives of dihydropyridines and the application of these reagents as precursors for N-centered radicals are presented. These aminated dihydropyridines could be used in radical-transfer hydroamination reactions of various electron-rich as well as nonactivated olefins in the presence of thiols as polarity-reversal catalysts. These reactions worked without the aid of any transition metal. Steric and electronic effects exerted by the N-substitutents of the N-centered radicals are discussed. In contrast to most metal-catalyzed processes, the radical hydroamination delivered the opposite regioisomer with excellent anti-Markovnikov selectivity. Hydroamination products were obtained as protected amines that are readily isolated. Festival of amination: We have presented an efficient synthesis of N-phthalimidyl, benzamidyl, acetamidyl, carbamoyl, and ureayl derivatives of dihydropyridines and the application of these reagents as precursors for N-centered radicals (see scheme). These aminated dihydropyridines can be used in radical-transfer hydroamination reactions.