1245651-80-2Relevant academic research and scientific papers
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-Arylthiazol-2-yl)-2-(3- methylcyclohexylidene)hydrazines
Chimenti, Franco,Secci, Daniela,Bolasco, Adriana,Chimenti, Paola,Granese, Arianna,Carradori, Simone,Yá?ez, Matilde,Orallo, Francisco,Sanna, M. Luisa,Gallinella, Bruno,Cirilli, Roberto
supporting information; experimental part, p. 6516 - 6520 (2010/10/20)
Novel 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine derivatives have been investigated for their ability to inhibit selectively the activity of the human B isoform of monoamine oxidase. These compounds were obtained as racemates and (R)-enantiomers by a stereoconservative synthetic pattern in high yield and enantiomeric excess. The (S)-enantiomers of the most active derivatives have been separated by enantioselective HPLC. All compounds showed selective activity against hMAO-B with IC50 ranging between 21.90 and 0.018 μM.
