1245730-45-3Relevant academic research and scientific papers
Electronic effects in 1,3-dipolar cycloaddition reactions of N-alkyl and N-benzyl nitrones with dipolarophiles
Bdoiu, Andrei,Kuendig, E. Peter
supporting information; experimental part, p. 114 - 121 (2012/01/06)
1,3-Dipolar cycloadditions afforded fast access to isoxazolidines bearing N-alkyl or N-benzyl substituents. The electronic properties of the substituents in the nitrones define the activity of the dipoles and modulate diastereoselectivity in the non-catal
Ruthenium lewis acid catalyzed asymmetric 1,3-dipolar cycloadditions between N -methylnitrones and enals
Badoiu, Andrei,Bernardinelli, Gerald,Kuendig, E. Peter
experimental part, p. 2207 - 2212 (2010/09/11)
N-Methylisoxazolidines are formed in good yields and high regio-, diastereo- and enantioselectivity via asymmetric 1,3-dipolar cycloaddition of nitrones with enals catalyzed by a chiral ruthenium Lewis acid. Electronic effects in the dipole are the key to activation of these substrates for efficient catalysis. Georg Thieme Verlag Stuttgart - New York.
