1245735-60-7

Basic information

• Product Name: C₂₂H₂₁NO₂S
• Synonyms: C₂₂H₂₁NO₂S
• CAS NO: 1245735-60-7
• Molecular Weight: 363.48
• Mol File: 1245735-60-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₁NO₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₁NO₂S(1245735-60-7)
• EPA Substance Registry System: C₂₂H₂₁NO₂S(1245735-60-7)

Safety Data

• Hazardous Substances Data: 1245735-60-7(Hazardous Substances Data)

Upstream product

• 1323252-69-2 (9-H-fluoren-9-yl)methanesulfonyl chloride 
• 64-04-0 phenethylamine 

Downstream Products

• 64-04-0 phenethylamine 
• 3278-14-6 N-phenethylbenzamide 

Relevant articles and documents

(9H-fluoren-9-yl)methanesuIfonyl (Fms): An amino protecting group complementary to Fmoc

A sulfonamide-based protecting group (PG), (9H-fluoren-9yl)methanesulfonyl (Fms), which can be used in a similar way to the well-established Fmoc PG, was developed. The advantages of this new PG were demonstrated in the successful formation of a phosphonamide between an N-Fmsprotected a-phosphonoalanine monoester and secondary alkylamines, including (R)-2-phenylethylamine, (S)-phenylalanine iert-butyl ester (H-Phe-OtBu), H-Pro-Gly-OtBu, and H-Phe-Phe-OtBu, without formation of oxazaphospholine, which is a serious problem associated with the Fmoc PG. The success should pave the way to the solid-phase synthesis of unnatural peptides substituted with a-amino phosphonic acid (AP) at essentially any arbitrary position without significant modification of the Fmoc-based chemistry that has been accumulated since Carpino's report in 1970. The N-Fms-AP monomer would attract much attention in the field of peptide mimetics.