1245751-08-9Relevant academic research and scientific papers
Room-temperature alternative to the arbuzov reaction: The reductive deoxygenation of Acyl phosphonates
Kedrowski, Sean M. A.,Dougherty, Dennis A.
supporting information; experimental part, p. 3990 - 3993 (2010/11/02)
The reductive deoxygenation of acyl phosphonates using a Wolff-Kishner-like sequence is described. This transformation allows direct access to alkyl phosphonates from acyl phosphonates at room temperature. The method can be combined with acyl phosphonate synthesis into a one pot, four-step procedure for the conversion of carboxylic acids into alkyl phosphonates. The methodology works well for a variety of aliphatic acids and shows a functional group tolerance similar to that of other hydrazone-forming reactions.
