1245751-10-3Relevant academic research and scientific papers
Synthesis of the phenylpyridal scaffold as a helical peptide mimetic
Bourne, Gregory T.,Kuster, Daniel J.,Marshall, Garland R.
supporting information; experimental part, p. 8439 - 8445 (2010/09/08)
Phenylpyridal- and phenyldipyridal-based scaffolds have been designed and synthesized as novel helical peptide mimetics. The synthesis required optimisation and selective alkylation in producing 2,6-functionalized 3-hydroxypyridine derivatives for a convergent scheme. The pyridine analogues were coupled by a series of Suzuki/Stille types cross-coupling reactions. A series of biaryl and ter-aryl substituted heterocycles were produced. The synthetic approach was concise and high yielding allowing large variability at the wanted sidechain attachment points. A number of compounds were synthesised to show the versatility of the strategy.
