124576-58-5Relevant academic research and scientific papers
Direct amination of β-oxo esters
Fioravanti, Stefania,Morreale, Alberto,Pellacani, Lucio,Tardella, Paolo A.
, p. 1171 - 1173 (2001)
The reaction of NsONHCO2Et, in the presence of CaO, with β-oxo esters gives the corresponding aminated products in yields up to 58%. A substrate carrying the Oppolzer sultam undergoes amination with 40% diastereoselectivity.
Easy access to α-amino β-oxo esters from β-enamino esters
Felice, Elena,Fioravanti, Stefania,Pellacani, Lucio,Tardella, Paolo A.
, p. 4413 - 4416 (2007/10/03)
N-Substituted α-amino β-oxo esters have been obtained by amination of β-enamino esters with ethyl N-[(4-nitrobenzenesulphonyl)oxy]carbamate (NsONHCO2Et), in the absence of added bases. The use of optically active pyrrolidines with C2 symmetry as chiral auxiliaries induces diastereoselectivities up to 80%.
