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1245770-92-6

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1245770-92-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1245770-92-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,7,7 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1245770-92:
(9*1)+(8*2)+(7*4)+(6*5)+(5*7)+(4*7)+(3*0)+(2*9)+(1*2)=166
166 % 10 = 6
So 1245770-92-6 is a valid CAS Registry Number.

1245770-92-6Downstream Products

1245770-92-6Relevant articles and documents

Enzymatic parallel kinetic resolution of mixtures of d / l 2′-deoxy and ribonucleosides: An approach for the isolation of β- L -nucleosides

Martinez-Montero, Saul,Fernandez, Susana,Sanghvi, Yogesh S.,Gotor, Vicente,Ferrero, Miguel

, p. 6605 - 6613 (2010)

We have developed a lipase-catalyzed parallel kinetic resolution of mixtures of β-d/l-nucleosides. The opposite selectivity during acylation exhibited by Pseudomonas cepacia lipase (PSL-C) with β-d- and β-l-nucleosides furnished acylated compounds that have different R f values. As a consequence, isolation of both products was achieved by simple column chromatography. Computer modeling of the transition-state analogues during acylation of β-d- and β-l-2′-deoxycytidine with PSL-C was carried out to explain the high selectivity. PSL-C favored the 3′-O-levulination of the β-d enantiomer, whereas the 5′-OH group was acylated in 2′-deoxy-β-l-cytidine. In both cases, the cytosine base was placed in the alternate hydrophobic pocket of PSLs substrate-binding site, where it can form extra hydrogen bonds (in addition to the five essential catalytically relevant hydrogen bonds) that stabilize these intermediates catalyzing the selective acylation of β-d/l-nucleosides.

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