1245819-37-7Relevant academic research and scientific papers
Rhodium-catalyzed Asymmetric Arylation of Nitroalkenes Powered by Simple Chiral Sulfur-Olefin Ligands
Wang, Zheng,Chen, Wen-Wen,Xu, Ming-Hua
, p. 331 - 336 (2017/12/04)
An efficient rhodium-catalyzed enantioselective addition of potassium organotrifluoroborates to nitroalkenes powered by simple chiral sulfur-olefin ligands is reported. This protocol is applicable to a broad range of 2-aryl-, alkyl-, and heteroaryl-substituted nitroalkenes, allowing access to diverse chiral β,β-disubstituted nitroethanes in good to excellent yields with high enantioselectivity under mild conditions.
Rhodium-catalyzed asymmetric 1,4-addition reactions of aryl boronic acids with nitroalkenes: Reaction mechanism and development of homogeneous and heterogeneous catalysts
Miyamura, Hiroyuki,Nishino, Kohei,Yasukawa, Tomohiro,Kobayashi, Shu
, p. 8362 - 8372 (2017/11/27)
Asymmetric 1,4-addition reactions with nitroalkenes are valuable because the resulting chiral nitro compounds can be converted into various useful species often used as chiral building blocks in drug and natural product synthesis. In the present work, asymmetric 1,4-addition reactions of arylboronic acids with nitroalkenes catalyzed by a rhodium complex with a chiral diene bearing a tertiary butyl amide moiety were developed. Just 0.1 mol% of the chiral rhodium complex could catalyze the reactions and give the desired products in high yields with excellent enantioselectivities. The homogeneous catalyst thus developed could be converted to a reusable heterogeneous metal nanoparticle system using the same chiral ligand as a modifier, which was immobilized using a polystyrene-derived polymer with cross-linking moieties, maintaining the same level of enantioselectivity. To our knowledge, this is the first example of asymmetric 1,4-addition reactions of arylboronic acids with nitroalkenes in a heterogeneous system. Wide substrate generality and high catalytic turnover were achieved in the presence of sufficient water without any additives such as KOH or KHF2 in both homogeneous and heterogeneous systems. Various insights relating to a rate-limiting step in the catalytic cycle, the importance of water, role of the secondary amide moiety in the ligand, and active species in the heterogeneous system were obtained through mechanistic studies.
Rhodium-catalyzed asymmetric conjugate addition of organoboronic acids to nitroalkenes using chiral bicyclo [3.3.0] diene ligands
Wang, Zhi-Qian,Feng, Chen-Guo,Zhang, Shu-Sheng,Xu, Ming-Hua,Lin, Guo-Qiang
supporting information; experimental part, p. 5780 - 5783 (2010/10/21)
(Figure Presented) Old before l diene: An efficient rhodium/ diene-catalyzed asymmetric conjugate addition of organoboronic acids to challenging nitroalkene substrates that lack α substituents has been developed. Chiral bicyclo[3.3.0] dienes were found to
