124582-37-2

Usage

Chemical Properties

Brown Oil

Upstream product

• 688-73-3 tri-n-butyl-tin hydride 
• 922-67-8 propynoic acid methyl ester 

Downstream Products

• 28042-27-5 α-Methylene-4-nitrobenzeneacetic acid methyl ester 
• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 103-26-4 Methyl cinnamate 
• 1160714-57-7 methyl 2-(4,5-dimethoxy-2-(((2-(2-methyl-1,3-dioxolan-2-yl)-1-(trimethylsilyl)ethyl)((trimethylsilyl)methyl)amino)methyl)phenyl)acrylate 
• 17647-39-1 3-phenyl-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester 
• 50415-68-4 methyl 2-(4-methoxyphenyl)prop-2-enoate 

Relevant academic research and scientific papers

Colorless to purple-red switching electrochromic anthraquinone imides with broad visible/near-IR absorptions in the radical anion state: Simulation-aided molecular design

The large redshift of near-infrared (NIR) absorptions of nitro-substituted anthraquinone imide (Nitro-AQI) radical anions, relative to other AQI derivatives, is rationalized based on quantum chemical calculations. Calculations reveal that the delocalization effects of electronegative substitution in the radical anion states is dramatically enhanced, thus leading to a significant decrease in the HOMO-LUMO band gap in the radical anion states. Based on this understanding, an AQI derivative with an even stronger electron-withdrawing dicyanovinyl (di-CN) substituent was designed and prepared. The resulting molecule, di-CN-AQI, displays no absorption in the Vis/NIR region in the neutral state, but absorbs intensively in the range of λ=700-1000 (λmax≈860 nm) and λ=1100-1800 nm (λmax≈1400 nm) upon one-electron reduction; this is accompanied by a transition from a highly transmissive colorless solution to one that is purple-red. The relationship between calculated radical anionic HOMO-LUMO gaps and the electron-withdrawing capacity of the substituents is also determined by employing Hammett parameter, which could serve as a theoretical tool for further molecular design.

Z-Selective Hydrostannylation of Terminal and Internal C-C Triple Bonds Initiated by the Trityl Cation

A metal-free method for the anti-addition of n-Bu3SnH across terminal and internal alkynes, including related α,β-unsaturated carboxyl compounds, is reported. The reaction is initiated by the trityl salt [Ph3C]+[B(C6F5)4]- and proceeds through β-tin-stabilized vinyl cations. Their reduction by hydride transfer from n-Bu3SnH explains the high Z-selectivity in the formation of the vinyl stannanes.

From Acenaphthenes to (+)-Delavatine A: Visible-Light-Induced Ring Closure of Methyl (α-Naphthyl) Acrylates

Disclosed herein is a visible light mediated cyclization of methyl (α-naphthyl) acrylates and heteroaromatic analogues yielding substituted acenaphthenes and azaacenaphthenes. This highly functional-group-tolerant transformation was put to the test in an enantioselective formal synthesis of delavatine A. Mechanistic details were elucidated by DFT-calculations revealing an unusual intramolecular H-transfer mediated by a primary amine. The generality of this transformation enables a novel synthetic strategy of five membered ring annulation at an advanced stage, allowing reliance upon naphthalene chemistry up to the point of acenaphthene construction.

3-[1,4]OXAZEPANE-4-PYRIMIDONE DERIVATIVES

A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom, C-F or the like; R1 represents a C1-C3 alkyl group; Y represents oxygen atom or N-R7; R2, R3, R4, R5, R6 and R7 each independently represents hydrogen atom, a C1-C6 alkyl group, or a group represented by the formula (II): which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).