124589-91-9Relevant academic research and scientific papers
Synthesis and biological evaluation of sulfur-containing cinnamate and salicylate derivatives
Chiang, Chih-Chia,Chang, Tsu-Chung,Tsai, Hou-Jen,Hsu, Ling-Yih
, p. 369 - 373 (2008/09/20)
UV irradiation induced formation of reactive oxygen radical species and matrix metalloproteinases (MMPs) are thought to be involved in photo-damage to the skin. MMP-1 is the major collagenolytic enzyme responsible for collagen destruction in skin tissue. To develop new anti-photoaging agents, a series of 2,2′-dithiocinnamate derivatives and 2,2′-dithio or 2-thiobenzoate derivatives were designed and synthesized. The biological activities of the synthesized compounds were assayed for ABTS [2,2′-azinobis-(3-ethyl-benzo- thiazoline-6-sulfonic acid)] radical scavenging activity, MMP-1 inhibitory activity, and cytotoxicity to human dermal fibroblast cells. Compounds with potential of resistance to UV irradiation were identified. These compounds are expected to be useful for preventing photo-damage to the skin.
