1245896-12-1

Basic information

• Product Name: [⁽¹²⁵⁾I]4-hydroxy-4-[4-(2-iodobenzyloxy)-phenyl]butanoic acid
• CAS NO: 1245896-12-1
• Molecular Weight: 410.32
• Mol File: 1245896-12-1.mol

Chemical Properties

• CAS DataBase Reference: [⁽¹²⁵⁾I]4-hydroxy-4-[4-(2-iodobenzyloxy)-phenyl]butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [⁽¹²⁵⁾I]4-hydroxy-4-[4-(2-iodobenzyloxy)-phenyl]butanoic acid(1245896-12-1)
• EPA Substance Registry System: [⁽¹²⁵⁾I]4-hydroxy-4-[4-(2-iodobenzyloxy)-phenyl]butanoic acid(1245896-12-1)

Safety Data

• Hazardous Substances Data: 1245896-12-1(Hazardous Substances Data)

Downstream Products

• 1245786-06-4 C₁₇H₁₆⁽¹²⁵⁾IO₄^(1-)*Na⁽¹⁺⁾ 

Relevant articles and documents

Radioiododestannyllation of novel GHB neuroreceptor ligands

A series of 4-substituted gamma-hydroxybutyric acid (GHB) analogues have previously been synthesized and characterized for binding to specific high-affinity GHB sites in rat brain cortical membranes.1,2 Within this series some halogenated analogues displayed unprecedented high affinity and selectivity for GHB sites, and would potentially be valuable as pharmacological tools if radiolabelled. Here we present the iodine-125 labelling of one of these analogues by radioiodo-destannylation. Copyright

Design, synthesis, and in vitro pharmacology of new radiolabeled γ-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity γ-hydroxybutyric acid binding sites

γ-Hydroxybutyric acid (GHB) is a psychotropic compound endogenous to the brain. Despite its potential physiological significance, the complete molecular mechanisms of action remain unexplained. To facilitate the isolation and identification of the high-affinity GHB binding site, we herein report the design and synthesis of the first 125I-labeled radioligands in the field, one of which contains a photoaffinity label which enables it to bind irreversibly to the high-affinity GHB binding sites.